82 Transmembrane signal transduction Concept ● Several main forms ck Mediated by ion channel k Mediated by g-protein coupled receptor k Mediated by tyrosine kinase receptor k Mediated by intercellular channel k Mediated by nitric oxide o Cellular proto-oncogene Mediate-early gene
§ 2. Transmembrane signal transduction • Concept • Several main forms * Mediated by ion channel * Mediated by G-protein coupled receptor * Mediated by tyrosine kinase receptor * Mediated by intercellular channel * Mediated by nitric oxide • Cellular proto-oncogene Mediate-early gene
*k Mediated by ion channel ionotropic receptor k Mediated by g-protein coupled receptor Metabotropic receptor, G-protein, effecter enzyme AC-CAMP-PKA PLC-IP-Ca2+- Cam PLC-DG-PKC G-protein-ion channel k Mediated by tyrosine kinase receptor Tyrosine kinase receptor receptor-associated tyrosine kinase
* Mediated by ion channel Ionotropic receptor * Mediated by G-protein coupled receptor Metabotropic receptor, G-protein, effecter enzyme AC-cAMP-PKA PLC-IP3 -Ca2+ -CaM & PLC-DG-PKC G-protein-ion channel * Mediated by tyrosine kinase receptor Tyrosine kinase receptor receptor-associated tyrosine kinase
3000NH 细胞外 8(Ⅳ abood 细胞内 N-ⅢC-Ⅲ POcooooooooo-CCOH A model of G-protein coupled receptor
A model of G-protein coupled receptor
神经递质与受体结合 O神经递质 受体 腺苷酸环化酶 000000000 GTP GTE 8(GDP cAMP G蛋白激活腺苷酸环化酶 cAMP激活蛋白激酶 蛋白激酶A G-protein coupled receptor mediated transduction
G-protein coupled receptor mediated transduction
生长因子 生长素受体 ←受体酪氨酸激酶 细胞龑 RR-CDP (失活) (\ CRB2 JAK RAB-CTP o 录酸化结构域 STAT 激活 Ref(MAPKKK (丝氨酸/苏氨酸激痛) TAT 激活 MAPKK (苏氨酸氨酸激鼻 STAT 激活MAFK (丝氨酸苏氨酸激痛) 转录因子磷酸化 转录因子病酸化 Tyrosine kinase receptor mediated transduction
Tyrosine kinase receptor mediated transduction