Pathophysiology DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY
11 DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY Pathophysiology
Pathophysiology Measles virus Respiratory epithelium regional lymph nodes 1.Incubation period First viremia 10-14 days ↓ Monocytes/Macrophage 2.Prodromal period Second viremia 3-4 days Respiratory tract, 3.Apparent conjunctiva,skin,etc manifestation period 3-5 days Virus elimination 4.Convalescent period 12 3-5 days
12 Respiratory epithelium regional lymph nodes First viremia Monocytes/Macrophage Second viremia Respiratory tract, conjunctiva, skin, etc Virus elimination Measles virus Pathophysiology 1. Incubation period 10-14 days 2. Prodromal period 3-4 days 3.Apparent manifestation period 3-5 days 4. Convalescent period 3-5 days
Pathology 13 DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY
13 DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY Pathology
● Pathology -Cytopathic change Multinucleated giant cell (Warthin-finkeldey giant cells) Φ=100μm,several nucleus inside the cell, formed by confluence of several virus infected reticuloendothelial cells In smears of the nasal mucosa in the prodromal stage PATHOGNOMONIC FOR MEASLES
14 Multinucleated giant cell (Warthin-finkeldey giant cells) Pathology – Cytopathic change PATHOGNOMONIC FOR MEASLES Φ= 100μm, several nucleus inside the cell, formed by confluence of several virus infected reticuloendothelial cells In smears of the nasal mucosa in the prodromal stage
Pathology Cytopathic change Multinucleated giant cell PATHOGNOMONIC PRESENTATION FOR MEASLES 5
15 Multinucleated giant cell Pathology – Cytopathic change PATHOGNOMONIC PRESENTATION FOR MEASLES