The antigen is not of glomerular (innocent bystander) It may be endogenous(SLe), or exogenous(bacterial, viral, parasitic and spirochetal infection). Sometimes the inciting antigen is unknown Antigen-antibody complexes are formed in situ or in the circulation and then trapped in the glomeruli, where they produce injury, in large part through the binding of complement. The glomerular lesions usually consist of leukocytic infiltration into glomeruli and proliferation of endothelial, mesangial and parietal epithelial cells. Deposits may be located at more than one site in a given case
The antigen is not of glomerular (innocent bystander). It may be endogenous (SLE), or exogenous (bacterial, viral, parasitic and spirochetal infection). Sometimes the inciting antigen is unknown. Antigen-antibody complexes are formed in situ or in the circulation and then trapped in the glomeruli, where they produce injury, in large part through the binding of complement. The glomerular lesions usually consist of leukocytic infiltration into glomeruli and proliferation of endothelial, mesangial and parietal epithelial cells. Deposits may be located at more than one site in a given case
CIRCULATING Size and Charge IMMUNE COMPLEX DEPOSITION Epithelial cell Foot processes Subepithelial deposit (rare) Basement membrane Endothelium Circulating complex Subendothelial eposit
Size and Charge
Immunofluorescence
Immunofluorescence
Pathogenesis Circulating immune complex Immune complex in situ E Cell-mediated immune Mediators of immune injury Other mechanisms
Circulating immune complex Immune complex in situ Cell-mediated immune Mediators of immune injury Other mechanisms Pathogenesis
e. Anti-GBM nephritis : Heymann nephritis
Anti-GBM nephritis Heymann nephritis