BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 Surface properties dominated by last layer deposited 图 s Polyanion 3)Polycation 2)Was Layer igure 2, Advancing contact angle as a function of the layer number --- termost layer, whereas even number films have chitosan as the outermost layer, Assemblyfiguresourcehttp://www.chem.fsuedu/multilayers/ mbly on complex surfaces o Polyelectrolytes will adsorb to surfaces with complex topography o Polyelectrolytes themselves may have complex geometries(e.g. particles or dendrimers )6 Scheme 1. Schematic llustration for the Preparation of Hollow 时9N2N9 PSS/4G PAMAM Multilayer Capsules 3. 4G PAMAM Colloid PSS/4G PAMAM- Generation 7 poly(amidoamine) dendrimer: template colloid coated colloid steps 1-4 Cure renoval PSS/4GPAMAM SS/4GPAMAM multilayer-coated colloid hollow capsule ( Khopade and Caruso, 2002) Dendrimerimagesourcehttp://www.foresight Lecture 9-polyelectrolyte hydrogels 60f17
BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 Surface properties dominated by last layer deposited: θ Assembly figure source: http://www.chem.fsu.edu/multilayers/ • Assembly on complex surfaces o Polyelectrolytes will adsorb to surfaces with complex topography o Polyelectrolytes themselves may have complex geometries (e.g. particles or dendrimers) 6 Generation 7 poly(amidoamine) dendrimer: (Khopade and Caruso, 2002) Dendrimer image source: http://www.foresight.org/Conferences/MNT7/Papers/Cagin3/ Lecture 9 – polyelectrolyte hydrogels 6 of 17
BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 o Assembly on protein crystals to encapsulate proteins: 7 Blahblah 1,02),etc e Figure 4. TEM decomposition ule spreads out on the carbon surfare on which it i creases can be seen, Same undecomposed enzyn mulyte can still be seen in the lnterior of the capsule. layer Fah pelyleetralyle Layr units (Caruso et al., 2000) Cells as living PEM assembly substrates (F. Caruso) (soUrce:http://ww.chem.fsuedu/multilayers/ o What else Building PEMs on biomaterials Assembly of PEMs on amino-modified poly(lactide)' o Alternating adsorption of sulfonated polystyrene and chitosan(polycation Lecture 9-polyelectrolyte hydrogels 7of17
BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 o Assembly on protein crystals to encapsulate proteins: 7 Blah blah (Caruso et al., 2000) • Cells as living PEM assembly substrates: SEM micrograph of multilayer-coated echinocyte blood cell (F. Caruso) (Source: http://www.chem.fsu.edu/multilayers/) o What else Building PEMs on biomaterials8 • Assembly of PEMs on amino-modified poly(lactide) 5 o Alternating adsorption of sulfonated polystyrene and chitosan (polycation) Lecture 9 – polyelectrolyte hydrogels 7 of 17