CCR5 CD4 C N
感解微斯 Fusion domain
E
HIV AEPLICATION CYCLE absorption to receptor vin gp120 S penetration a: call surface c ar uptake into vacuole CDd 'EsPn at viral envelope wth call terse membrane transcriptase want DNA ligat penetration nosE a host integration Transcription Ss RNA viral mRNA L Progeny RNA translat Mrai proteins assembl wral ere ope 《》 erBens
Viral dynamics in a typical HⅣ+ person[1] . Error frequency in RT:3 x 10-5 per base per replication cycle .HIV-1 genome is composed of 104= 10,000 nucleotides oup to 10 billion viruses are produced daily 100 million new cell infections/day 10 million viruses per day with one new error (mutation)
Viral dynamics in a typical HIV+ person[1] •Error frequency in RT: 3 x 10-5 per base per replication cycle •HIV-1 genome is composed of 104 = 10,000 nucleotides •up to 10 billion viruses are produced daily •100 million new cell infections/day •10 million viruses per day with one new "error" (mutation)