NCBI Resources回 How To回 lipengryuan M NcBI Sign Out PubmEd Advanced Format: Abstract Send to Full text fi scnc2016Ma18351(627913436do101176 scince aad6117Epu27016Fe25 Structural and molecular basis for Ebola virus neutralization by protective human antibodies ISc MisasiI', Gilman MS. Kanekyo M, GuiM Canio A, Mutangu s, Cort D, Leggenood E. La L', Graham BS. Xiang Y o, Sullivan N, McLellan s2 Author information 食 Add to Favorites Abstract Ebola virus causes hemorrhagic fever with a high case fatality rate for which there is no approved therapy. Two human monoclonal antibodies mAb100 and mAb114, in combination, protect nonhuman primates against all signs of Ebola virus disease, including viremia. Here, we Similar articles emonstrate that mAb100 recognizes the base of the Ebola virus glycoprotein (GP)trimer, occludes access to the cathepsin-cleavage loop, and Review Structural basis for differential prevents the proteolytic cleavage of GP that is required for virus entry. We show that mAb114 interacts with the glycan cap and inner chalice of neutralization of ebolaviruses. Viruses. 2012) GP, remains associated after proteolytic removal of the glycan cap, and inhibits binding of cleaved GP to its receptor. These results define the Molecular characterization of the monoclonal basis of neutralization for two protective antibodies and may facilitate development of therapies and vaccines antibodies composing ZMAb: a pr [Sci Rep. 2014 Copynight o 2016, American Assocation for the Advancement of Science Antibody-mediated neutral ization of Ebola virus an occur by two distinct mechan [Virology. 2010) PMID 26917592 Dot 10 scance aaot Characterization of a Novel Neutralizing tMnd· indexed for MEDUN臼 Monoclonal Antibody Against I [J Infect Dis. 2015 图园 Review Neutralizing ebolavirus; structural insights into the enve [Curr Opin Struct Biol. 2009) See reviews Publication Types, MeSH Terms, Substances, Secondary Source ID, Grant Support LinkOut. more resources Cited by 4 PubMed Central articles PubMed Commons PubMed Commons home with therapeutic antibodies. [Nat Microbiol.2016) Clomiphene and Its Isomers Block Ebola Virus Particle Entry and Infection with S VIruses. 2016] How tojoin PubMed Common Potent neutralizing monodonal antibodies against Ebola virus infection. [Sci Rep. 2016) See Rh Structures reported by this article Antibodies 100 And 114 In
f1000 corm/prime m☆ FroOPrimo FIOOResoarch Froooworkspace Welcome #I Third MintaryMMedeal University FIOOO Prime Article Reyommendations-ebolavi Irus Q)Advance REPORTS I F1000 FACULTY I BI Myf1000 1 SIGN OU My F1000Prime Homepage Retm to armend Based on your interactions and Sections/Keywords, these articles should be relevant or interesting to you. Increase relevancy over time by telling us which articles in the PubMed list are not relevant to your research Explore your selected Sections Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 a inflammasome-dependent production of prostaglandins Protein Prevents DNA Damage yrkalska SD, Candel S, Angosto D, Gomez-Abellan V z-Fermer A, Sepulcro MP, Pelegrin ost Nitrogen Immune Response Aulero V.+ Nat Commun, 2010: 7: 12077 11 Recomm n a NER-ndependent but RecBC-Depe Pathway. Arrigo C, Guillemet E, Dervyn R: Ramarao N. PLoS OMNE2016:11(10)e0163321 D save/ Follow 5) Get Artiele thins Nominate for inclusion in F1000Prime b I save/Follow Innate immune responses in hepatitis B virus(HBV) infection A, Kumar A Virol J, 2014: 11: 221 1 Rec DNA damage responses and stress resistance: Concepts from bacterial sos to metazoan natural hstory or hepatis B vinus (HBV) infecton resutts tom a complex dynamic interaction between the virus and is bosts immune defenses. This article provides a useful Williams AB, Schumacher B, Mach Ageing Dev 2016 Sep 26 D Save/ Follow. Got Artide Exthis wn Nominate for inclusion in F1000Prime D C save/Follow 2“m progressing Hiv-infected children share fundamental immunological features manara o, Crowther C Jooste P, Moore PL. Morris L Goulder P.+ IRGB10 Liberates Bacterial Ligands for Sensing luencthoff M Acand E Sci Transl Med, 2016 Sep 28: 8(358): 358ra125|1 Recommendation b by the AIM2 and Caspase-11-NLRP3 leads to the development of AIDs largely due to prolonged hign ieve of mmune activation. This study by an sM, Kark R. Sasai M, Place DE. Neale G, Brown 5A. Yamamoto M, Kanneganul TD, Cell 2016 Sep O save/ Follow a Get Article tatars Nominate for inclusion in F1000Prime D a save/ Follow STING Requires the Adaptor TRIF to Trigger Innate Immune Responses to icrobial Infection /ang x, Majumdar T Kessler P, Ozhegov E, Zhang Y, Chattopadhyay s, Bank S Son GC Cell Host MIcrobe 2016 Sep 14: 20(3): 329-411 1 Recommendation P This study advances our understanding of the mechanisms of signa fing for defense that are activated I by foreign DNA through the function of the signaling protoin STING. Italso FOLLOWING RECOMMENDED O save/ Follow.) Get Articie Athis FACULTY MEMBERS
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FoooPrime FoooResearch Floooworkspace Welcome l Third Military Medical University FlOO Prime Article Recommendations ebolavirus Advanced ARTICLE RECOMMENDA TONS I RANKINGS I F10O0PRIME REPORTS I F1000 FACULTY I BLOG MyF1000 SIGN OUT ALL SEARCH F1000 3 colani RESULTS 1,SEARCN(RESULTS Artcle Article Recommendations sarch for ebolavirus" hns 11 resuits n Article Recommendations I STORE SEARCH and sot up Emad Alart Facuty Recommended in the pest All Tirme REFINE SEARCH Hoby accessed Search ebolavirs-in 3 Antibody Treatment of Ebola and sudan Virus Infection via a e Uniquely Exposed Epitope within the Glycoprotein Receptor Binding Site Howell KA, Qiu X, Brannan JM, Bryan C, Davidson E, Holtsberg FW, Wec AZ, Shulenin s, Biggins JE, Douglas R, Enterlein SG. Turner HL, Pallesen J, Munin CD. He S, Kroeker A, Vu H, Herbet AS fields Fusco ML, Nynsatura EK. Lal JR, Keck zY, Foung SK, Sa L, Ward AB, Chandran K Doranz BJ, Kobinger GP, Dye JM, Aman MJ. Cell Rep 2016 May 17: 15(7):1514-26 Article publication date 1 Recommendation I Anne Moscona with Laura M Palermo 16 201e Recommended in the past NEW I NOVEL DRUG TARGET Al tune novirus receptor NPC1. This crest region is conserved among ebolavinuses, suggesting that FVMO4 could.) Faculties of ebolavirus glycoproteins have been unsuccessful, largely because the RBS is occluded on the viral surtace Anesthesiology Pan atcs &Comp Discovery of swine as a host for the Reston ebolavirus Cardiovascular Bology Barrette RW, Metwally SA, Rowland Batten B, Sealy TK, Carrillo C, Moran KE I JM, Xu L, Zak SR, Nichol ST, Rolin PE, Towner JS, Shieh WJ. Article type auther EA, Ksazek TG, white WR, Mclntosh MT Science. 2000 Jul 10: 325(5937):204-6 1 Recommendation I David Wang 30 J 2009 Cinical Tral: Nor-RCT Chiral Trn RCT NEW FINDING reproductive and respiratory disease syndrome, have now been discovered to host Reston ebolavirus (REBOV
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纲 EMBASE数据库简介 EMBASE的各种检索方法和浏览方 法 EMBASE检索结果的处理 EMBASE数据库检索小结
EMBASE数据库检索内容提 纲 ➢ EMBASE数据库简介 ➢ EMBASE的各种检索方法和浏览方 法 ➢ EMBASE检索结果的处理 ➢ EMBASE数据库检索小结