The Complement System kills microbes via the Membrane Aftack Complex(MAC). C5b,67 complexes C8 binds to the complex C9 molecules bind to 10-16 molecules of C9 C5b binds C6 and C7 bind to membrane and inserts into the complex bind to fomm a pore via C7 the cell membrane and polymertze in the membrane C5.67 Pathogen 1997 Current Biology Lfd./Garland Publishing.Inc. Membrane lesions-end on(rings) Membrane lesions-side on (tubes) Schematic representation of the membrane-atiack complex pore 3nm 10rm
The Complement System kills microbes via the Membrane Attack Complex (MAC)
Activation of the Complement System 2 activation pathways are components of innate immunity Alternative pathway, Lectin pathway The Classical pathway of complement activation is part of the adaptive immune response dependent on Abs
Activation of the Complement System 2 activation pathways are components of innate immunity : Alternative pathway, Lectin pathway The Classical pathway of complement activation is part of the adaptive immune response - dependent on Abs