神经元一计算 Na cortical CH neuron(in vivo thalamocortical (TC)neuron(in vivo) endnote Soma/Axon KS K B c 600pA 80 mV cortical IB neuron(in vitro -20m 100 ms 60 mV 20 mV pre-Botzinger bursting neuron(in vitro) 人 60 mV
神经元-计算
CA1锥体神经元-S分岔现象 量‖b 5343321当39自 r=0.3
CA1锥体神经元-ISI分岔现象 b
神经元-S,AMP分岔现象 125128227228129 clanking) B r=0.8 Time(ms) =0.6 o.8
神经元-ISI,AMP分岔现象
神经元兴奋性 Class 1 Neural Excitability Class 2 Neural Excitability f40, CI lass 1 excitability 仝 Class 2 excitability 250 g200 30 g F-I curve g20 F-I curve 100 200 300 500 1000 1500 jected dc-current, I(pA) injected dc-current, I(pA)
神经元兴奋性
curves for simple models of type 1 and A type 2 behavior A: 6-variable Connor 3 20 et al. model of molluscan neuron 8150 NE incorporating A-type K+conductance showing type 1 50 behavior(Connor et al.1977) 100150200 B: 4-variable (A/cm) I (HA/cm) Hodgkin-Huxley model of the squid 250 giant axon membrane Zoo patch, showing type 2 behavior(Hodgkin and Huxley 1952) 910 C: 2-variable morris ecar model with type 1 parameters lorris and lecar 50100150200 % 1981) I HA/cm) I HA/cI D: Morris-Leca model with type 2 parameters
• f–I curves for simple models of type 1 and type 2 behavior. • A: 6-variable Connor et al. model of molluscan neuron, incorporating A-type K+conductance, showing type 1 behavior (Connor et al. 1977). • B: 4-variable Hodgkin–Huxley model of the squid giant axon membrane patch, showing type 2 behavior (Hodgkin and Huxley 1952). • C: 2-variable Morris– Lecar model with type 1 parameters (Morris and Lecar 1981). • D: Morris–Lecar model with type 2 parameters