Medical Genetics From his previous work with blood he knew that red blood cells were little more than bags filled with hemoglobin the molecule that carried oxygen from the lungs to the body
Medical Genetics From his previous work with blood, he knew that red blood cells were little more than bags filled with hemoglobin, the molecule that carried oxygen from the lungs to the body
Medical Genetics If the sickled cells had changed shape, perhaps it was because the hemoglobin had been altered in some way, making it clump and stick to one another, as antigens stick to antibodies. Pauling had already shown that hemoglobin changed shape slightly when it was oxygenated
Medical Genetics If the sickled cells had changed shape, perhaps it was because the hemoglobin had been altered in some way, making it clump and stick to one another, as antigens stick to antibodies. Pauling had already shown that hemoglobin changed shape slightly when it was oxygenated
Medical Genetics In the fall of 1946, Pauling presented his ideas as a research problem to Harvey itano, a young physician who was then working on a Ph. D. in his laboratory. Itano, worked for a year trying to see if sickle-cell hemoglobin was shaped differently from normal hemoglobin
Medical Genetics In the fall of 1946, Pauling presented his ideas as a research problem to Harvey Itano, a young physician who was then working on a Ph.D. in his laboratory. Itano,worked for a year trying to see if sickle-cell hemoglobin was shaped differently from normal hemoglobin
Medical Genetics In 1949, using an exquisitely sensitive new technique called electrophoresis that separated molecules by their electric charge, they found their answer: sickle-cell hemoglobin carried more positive electric charges on its surface
Medical Genetics In 1949, using an exquisitely sensitive new technique called electrophoresis that separated molecules by their electric charge, they found their answer: sickle-cell hemoglobin carried more positive electric charges on its surface
Medical Genetics This was an astounding discovery. a slight change in the electrical charge of a single type of molecule in the body could spell the difference between life and death This discovery--to which Pauling attached the memora ble title " molecular disease --received widespread attention
Medical Genetics This was an astounding discovery. A slight change in the electrical charge of a single type of molecule in the body could spell the difference between life and death. This discovery--to which Pauling attached the memorable title "molecular disease"--received widespread attention