Anhui Medical University 1.1 Fibroblast Fibroblasts are the principal cells of LCT. Structure LM:ovoid or stellate in shape,with long, tapering processes,one elliptical,pale- staining nucleus,weakly basophilic cytoplasm.But in routine histological preparations,only the nucleus of the fibroblast can be identified,the cytoplasmic processes blend in the surrounding fibers. Section of rat skin.A CT layer(dermis)shows several fibroblasts(F),which are the elongated cells
Structure LM: ovoid or stellate in shape, with long, tapering processes, one elliptical, palestaining nucleus, weakly basophilic cytoplasm. But in routine histological preparations, only the nucleus of the fibroblast can be identified, the cytoplasmic processes blend in the surrounding fibers. 1.1 Fibroblast Fibroblasts are the principal cells of LCT. Section of rat skin. A CT layer (dermis) shows several fibroblasts (F), which are the elongated cells. Anhui Medical University
Anhui Medical University EM:the cytoplasm to be rich in rough endoplasmic reticulum (RER),Golgi complex and free ribosomes. 1μm her magnification EM of part of the cell body of a fibroblast Ri Nucleus of fibroblast. Ri:free ribosomes GC:Golgi complexes Mi:mitochondria
EM: the cytoplasm to be rich in rough endoplasmic reticulum (RER), Golgi complex and free ribosomes. Higher magnification EM of part of the cell body of a fibroblast Ri: free ribosomes GC: Golgi complexes Mi: mitochondria Anhui Medical University
Anhui Medical University Function of fibroblasts Synthesize and secrete proteins(form collagen, reticular and elastic fibers and components of ground substances) Production of growth factor that influence cell growth and differentiation
Function of fibroblasts Synthesize and secrete proteins (form collagen, reticular and elastic fibers and components of ground substances) Production of growth factor that influence cell growth and differentiation Anhui Medical University
Anhui Medical University The common features of protein-secreting cells Basophilic cytoplasm under LM Rich in organelles associated with protein synthesis and secretion,such as RER,Golgi complex and free ribosomes. Such as fibroblast,plasma cell,osteoblast et al
The common features of protein-secreting cells Basophilic cytoplasm under LM Rich in organelles associated with protein synthesis and secretion, such as RER, Golgi complex and free ribosomes. Such as fibroblast, plasma cell, osteoblast et al. Anhui Medical University
Anhui Medical University Fibrocyte oIn mature CT,these cells are relatively inactive and immobile and are often called fibrocytes. After injury and during wound repair,they rapidly proliferate and become active fibroblasts to synthesize new ECM,including fibers and ground substance. Fibroblasts and fibrocytes Two stages of activity of the same cell-active and quiescent
* Fibrocyte In mature CT, these cells are relatively inactive and immobile and are often called fibrocytes. After injury and during wound repair, they rapidly proliferate and become active fibroblasts to synthesize new ECM, including fibers and ground substance. Fibroblasts and fibrocytes • Two stages of activity of the same cell-active and quiescent Anhui Medical University