Retinoblastoma %o A rare malignant tumor of the developing retina that occurs in children, usually before the age of four vears %o An abnormal appearance of the pupil which reflects light like a cat's eve
Retinoblastoma ❖ A rare malignant tumor of the developing retina that occurs in children, usually before the age of four years. ❖ An abnormal appearance of the pupil which reflects light like a cat's eye
Retinoblastoma %o A rare malignant tumor of the developing retina that occurs in children, usually before the age of four vears %o An abnormal appearance of the pupil which reflects light like a cat's eve Some forms represent a deletion in the region 13q14.1-g142
Retinoblastoma ❖ A rare malignant tumor of the developing retina that occurs in children, usually before the age of four years. ❖ An abnormal appearance of the pupil which reflects light like a cat's eye. ❖ Some forms represent a deletion in the region 13q14.1-q14.2
Two Mutation Theory 4 Knudson(1971)
Two Mutation Theory ❖ Knudson (1971)
Two Mutation Theory For familial cases & Two mutations are required, one in each copy of the rB gene The first mutation is present in the germline and thus in all cells of the body 8 The second somatic mutation is necessary for initiating tumor formation
Two Mutation Theory ❖ Two mutations are required, one in each copy of the RB gene ❖ The first mutation is present in the germline and thus in all cells of the body For familial cases ❖ The second somatic mutation is necessary for initiating tumor formation
Clone Origin Theory Inherited cancer Initiation ∧A入 Promotion
Inherited cancer Initiation Promotion Clone Origin Theory