Rheumatic fever (RF) a This is a multisystem disease and an acute, often recurrent, inflammatory disease principally of children that generally follows a pharyngeal(but not skin) infection with group a beta-hemolytic streptococci
Rheumatic fever (RF) ◼ This is a multisystem disease and an acute, often recurrent, inflammatory disease principally of children that generally follows a pharyngeal(but not skin) infection with group A beta-hemolytic streptococci
immune response throat Lymph node B lymphocytes Antistrep B-hemolytic antibodies streptococcu ACUTE RHEUMATIC HEART DISEASE CROSS-REACTIONS Vegetations Myocardial Aschoff body Fibrinous pencarditis
RF is a systemic disorder affecting Heart: pericarditis, myocarditis, and endocarditis, joint: polyarthritis skin: subcutaneous nodules and erythema ④ arteries: arteritis
◼ RF is a systemic disorder affecting: ◼ ①heart: pericarditis, myocarditis, and endocarditis; ◼ ②joint: polyarthritis; ◼ ③skin: subcutaneous nodules and erythema; ◼ ④arteries: arteritis
Aschoff bodies constitute foci of fibrinoid necrosis surrounded by lymphocytes macrophages, an occasional plasma cell and plump"activated "histiocytes called Anitschkow cells or aschoff cells lesions stimulate fibroblast proliferation and lead to scarring
◼ Aschoff bodies constitute foci of fibrinoid necrosis surrounded by lymphocytes, macrophages, an occasional plasma cell, and plump “activated” histiocytes called Anitschkow cells or Aschoff cells. Lesions stimulate fibroblast proliferation and lead to scarring
Aschoff nodule at high magnification. The most characteristic component is the Aschoff giant cell. Several appear here as large cells with two or more nuclei that have prominent nucleoli
Aschoff nodule at high magnification. The most characteristic component is the Aschoff giant cell. Several appear here as large cells with two or more nuclei that have prominent nucleoli