Atrophy(萎缩) o Shrinkage in the size of the normal cell, tissue and organ by the loss of cell substance o Decrease in Cell size or number
Atrophy (萎缩） ⚫ Shrinkage in the size of the normal cell, tissue and organ by the loss of cell substance. ⚫ Decrease in Cell size or number
Causes and types 1. Aging (生理性) 2. Inadequate nutrition/ diminished blood supply (营养不良性) 3. Pressure (压迫性) 4. Reduced functional activity(废用性) 5. Interrupted nerve supply 层去神经性) 6. Endocrine deficiency (内分泌性)
Causes and types 1. Aging (生理性~) 2. Inadequate nutrition/ diminished blood supply (营养不良性~) 3. Pressure (压迫性~) 4. Reduced functional activity (废用性~) 5. Interrupted nerve supply (去神经性~) 6. Endocrine deficiency (内分泌性~)
正胞 老年佐委绪胞 右侧为80岁老人脑,与正常脑相比,体积缩小,脑回变窄,脑沟加深
压迫性脑萎缩 Pressure atrophy of brain 标本为额状切面的脑组 织,暴露了侧脑室的前 后角,双侧侧脑室明显 扩张,脑实质变薄
Pathologic changes Grossly The entire tissue or organ diminishes in size weight and function Microscopically 1. Organelles degradation 2. Increased autophagic vacuoles 3. Residual bodies(e. g, lipofuscin)
Pathologic changes Grossly: The entire tissue or organ diminishes in size ,weight and function. Microscopically: 1. Organelles degradation 2. Increased autophagic vacuoles 3. Residual bodies(e.g., lipofuscin)