E coli fimbriae Type 1 mannose lactose g glycoli pids glycoproteins
E. coli fimbriae mannose Type 1 • galactose – glycolipids – glycoproteins P
Blood stream Hematogenous Ascend ing E. coli-urinary tract infection Is the leading cause of urinary tract infections which can lead to acute cystitis(bladder infection) and pyelonephritis(kidney infection)
E.coli-urinary tract infection Is the leading cause of urinary tract infections which can lead to acute cystitis (bladder infection) and pyelonephritis (kidney infection)
E. coli-Meningitis and Sepsis o Neonatal meningitis is the leading cause of neonatal meningitis and septicemia with a high mortality rate. Usually caused by strains with the Kl capsular antigen
E.coli-Meningitis and Sepsis ⚫ Neonatal meningitis – is the leading cause of neonatal meningitis and septicemia with a high mortality rate. Usually caused by strains with the K1 capsular antigen
Enteropathogenic E. coli fever infant diarrhea vomitin nausea non-bloody stools Destruction of surface microvilli loose attachment mediated by bundle forming pili (bip); Stimulation of intracellular calcium level: rearrangement of intracellular actin
Enteropathogenic E. coli ⚫ fever ⚫ infant diarrhea ⚫ vomiting ⚫ nausea ⚫ non-bloody stools ⚫ Destruction of surface microvilli 1. loose attachment mediated by bundle forming pili (Bfp); 2. Stimulation of intracellular calcium level; 3. rearrangement of intracellular actin
Enterotoxigenic E coli o A watery diarrhea, nausea, abdominal cramps and low-grade fever for 1-5 days o Travellers diarrhea and diarrhea in children in developing countries o Transmission is via contaminated food or water
Enterotoxigenic E. coli ⚫ A watery diarrhea, nausea, abdominal cramps and low-grade fever for 1-5 days. ⚫ Travellers diarrhea and diarrhea in children in developing countries ⚫ Transmission is via contaminated food or water