Medical Genetics Pedigree 口me■ affected male K dec ceased male oene● affected femal deceased female
Medical Genetics
Medical Genetics AUTOSOMAL X-LINKED RECESSIVE RECESSIVE O● 百6 PEDIGREE ANALYSIS SYMBOLS AUTOSOMAL Male DOMINANT Female ●od Parena, and children [I boy, I grt
Medical Genetics
Medical Genetics 2. autosomal dominant inheritance The pattern of autosomal dominant inheritance is perhaps the easiest type of Mendelian inheritance to recognize in a pedigree. One dose of the mutant gene, one mutant allele, is all that is required for the expression of the phenotype
Medical Genetics 2. autosomal dominant inheritance The pattern of autosomal dominant inheritance is perhaps the easiest type of Mendelian inheritance to recognize in a pedigree. One dose of the mutant gene, one mutant allele, is all that is required for the expression of the phenotype
Medical Genetics There are three reasons why an individual with an autosomal dominant disease should always be considered as being a heterozygote until proven otherwise
Medical Genetics There are three reasons why an individual with an autosomal dominant disease should always be considered as being a heterozygote until proven otherwise
Medical Genetics A. The disease is usually rare, with only about 1/10,000 individuals affected as an order of magnitude. Affected individuals are most likely to come from affected by normal matings. The normal parent is homozygous recessive, thus assuring that each product of the mating has at least one normal gene
Medical Genetics A. The disease is usually rare, with only about 1/10,000 individuals affected as an order of magnitude. Affected individuals are most likely to come from affected by normal matings. The normal parent is homozygous recessive, thus assuring that each product of the mating has at least one normal gene