Linkage Analysis Neurofibroma, NFl RFLP Ⅲ 2345678 4.7kb 30kb一一
Linkage Analysis Neurofibroma, NF1 RFLP Ⅰ Ⅱ Ⅲ 1 2 1 2 3 4 5 6 7 8 1 2 3 4 5 6 7 8 4.7 kb 3.0 kb
Linkage Analysis 1955, Morton: logarithm of the odds ( Lod) &+3 is considered evidence for linkage 2 is considered evidence for not linkage
Linkage Analysis 1955, Morton: logarithm of the odds (Lod) ❖ +3 is considered evidence for linkage ❖ -2 is considered evidence for not linkage
Multipoint Linkage Mapping ☆ Three point crosses
Multipoint Linkage Mapping ❖ Three point crosses
Somatic hvbridization Cell fusion: The experimental formation of a single hybrid cell with nuclei and cytoplasm from different somatic cells ☆ Sendai virus go Polyethylene Glycol, PEG 令 Electroporation
Somatic Hybridization Cell fusion: The experimental formation of a single hybrid cell with nuclei and cytoplasm from different somatic cells. ❖ Sendai virus ❖ Polyethylene Glycol, PEG ❖ Electroporation