HLA Class I and ll Molecules Have a Distinct Structure and Function .Binds 8-10mers ·Binds13-25mers .Expressed on most .Expressed on APCs, Nucleated cells Macs,B cells,activated .Presents Cytosolic T cells Proteins to CD8+T cells .Presents Vesicular Proteins to CD4+T cells 02 a1β1 B2 02 B2 ClassI Class ll BDC
2 3 1 2 1 2 1 2 •Binds 8-10mers •Expressed on most Nucleated cells •Presents Cytosolic Proteins to CD8+ T cells •Binds 13-25mers •Expressed on APCs, Macs, B cells, activated T cells •Presents Vesicular Proteins to CD4+ T cells Class I Class II HLA Class I and II Molecules Have a Distinct Structure and Function BDC
Cis and Trans-Class ll Dimerization DQA1 DOB1 Maternal 0501 0201 cis 做 DQA1*0501/DQB1*0201 0301 0302 CIS Paternal trans DQA1*0301/DQB1*0302 黛 打滋 DQA1*0301/DQB1*0201 DQA1*0501/DQB1*0302 BDC
0501 0201 0301 0302 cis cis DQA1 DQB1 trans DQA1*0301/DQB1*0201 DQA1*0501/DQB1*0302 DQA1*0501/DQB1*0201 DQA1*0301/DQB1*0302 Maternal Paternal Cis and Trans- Class II Dimerization BDC