juxtaglomerular apparatus 近球小体 (1)juxtaglomerular cells.球旁细胞 球旁器主 肾小裳 Role:Secret renin 要分布在 皮质肾单 肾小球上皮 (2)Mesangial cells 位，图而 球旁细胞 系膜细胞 皮质肾单 位含肾素 入球小 动脉 (3)macular densa 较多，对 致密斑 平滑肌细胞 尿的生成 榛盆毙 60 致密斑 基膜 起主要作 Sensing changes in 远曲小蕾 用。 球旁器结构图 volume,[Na+]
juxtaglomerular apparatus 近球小体 (1)juxtaglomerular cells球旁细胞 Role: Secret renin (2)Mesangial cells 系膜细胞 (3)macular densa 致密斑 Sensing changes in volume, [Na+]
renal blood supply characters of renal blood supply ①high blood flow.1200 Cortical nephron Efferent ml/min,or 21 percent of arteriole Afferent Juxtamedullary arteriole nephron the cardiac output. Interlobular artery vein 2maldistribution of blood uaino auoz Jaino Interlobar I hick flow in kidney Jeuul artery Vasa oop vein recta of Henle 94%to the cortex, Collecting duct Thin oop 外髓(outer zone) 5≈6% of Henle 内髓(inner zone) 1% Ducts of Bellini
① high blood flow. 1200 ml/min, or 21 percent of the cardiac output. ②maldistribution of blood flow in kidney 94% to the cortex, 外髓(outer zone) 5～6% 内髓(inner zone) 1% renal blood supply characters of renal blood supply
18 mm Hg ③Two capillary 60 mm Hg beds(两套毛细血管网) 100 mm Hg High hydrostatic 18 mm Hg pressure in 10 mm Hg 13 mm Hg glomerular capillary (about 60 mmHg) 10 mm Hg and low hydrostatic pressure in peritubular capillaries (about 13 8 mm Hg mmHg) Interstitial fluid pressure 6 mm Hg 0 mm Hg
③Two capillary beds(两套毛细血管网) High hydrostatic pressure in glomerular capillary (about 60 mmHg) and low hydrostatic pressure in peritubular capillaries (about 13 mmHg)
regulation of blood flow in kidney (1)autoregulation 2 肾血浆流量 肾小球滤过率 0 6.67 13.3 20.0 26.7 肾血流和肾小球滤过率 的自身调节
regulation of blood flow in kidney (1)autoregulation
Myogenic mechanism肌原学说 Arterial blood pressuret Short,wide Low-resistance afferent arteriole input pathway contraction of the vascular Filtration smooth muscle Filtrate constriction of the blood Bowman's capsule Glomerulus vessel Flow controlled by the blood flow relatively vasoconstriction of afferent arteriole Efferent arteriole=High-resistance constant plus vasa recta outflow pathway
Myogenic mechanism肌原学说