Epinephrine 10M) AMPLIFICATION Receptor G protein Ad AM PLIFICATION cyclase 3°5-AMP (10M) Protein AM PLIFICATION kinase A Modified AM PLIFICATION enzyme Metabolic product Cascade organization and amplification during signal Transduction 肾上腺素刺激下的信号放大
肾上腺素刺激下的信号放大
■信号转导有通用性、特异性 ■胞内信号转导途径相互交叉
◼ 信号转导有通用性、特异性 ◼ 胞内信号转导途径相互交叉
wT→(HM)→Dw rllgrownh factors fe. g TGFB (GFIR) cel→〔 :Cacheris 阝 C4HITCp .CdG2--- R50 ECM-+( Inia Crcl D:COM4H-pIs Rb +HPV E7 NFI s MKKt-JNK-+Jun CYcl E: CDK2- →R90+阳→艇随一MA二中 DIA damaga 影,TGFa n Gene PraiMrraden . MEKK (Cell Cycle Hormones ccaR+刚==== Bms的+TMR→+A。+A EB一 s AnP- MDM2 e得 Estrogen P NHR(a R ER ,mm1mmm大 eel Dath --Dc1 2 sbaI 3.5 FTEN FAP非 Cytochrome c ata----.日axL B02 Bed Mitochondna Jala abn a.g. FBBLJ cytoKines |3)
细胞信号转导联盟 ■多个研究单位参与组成国际性的研究组织,以 “G蛋白介导和与其相关的信号转导系统”为研 究对象,不仅包括涉及G蛋白的蛋白质,还有所 有信号相关蛋白间的相互作用关系和信号通路 对揭示生命本质,探讨疾病机制和新型药物筛选 有重大意义
细胞信号转导联盟 ◼ 多个研究单位参与组成国际性的研究组织，以 “G蛋白介导和与其相关的信号转导系统”为研 究对象，不仅包括涉及G蛋白的蛋白质，还有所 有信号相关蛋白间的相互作用关系和信号通路。 ◼ 对揭示生命本质，探讨疾病机制和新型药物筛选 有重大意义
a 1992: Reversible protein phosphory lation as a biological regulatory mechanism a 1994: G-proteins and the role of these proteins in signal transduction in cells a 1998: Nitric oxide as a signalling molecule in the cardiovascular system a 2000: Signal transduction in the nervous system 2004: odorant receptors and the organization of the olfactory system
◼ 1992: Reversible protein phosphorylation as a biological regulatory mechanism ◼ 1994: G-proteins and the role of these proteins in signal transduction in cells ◼ 1998: Nitric oxide as a signalling molecule in the cardiovascular system ◼ 2000: Signal transduction in the nervous system ◼ 2004: odorant receptors and the organization of the olfactory system